Sensitive Synaptotagmin 7 And The

Overview of Sensitive Synaptotagmin 7 And The

Synaptotagmin-7 outperforms synaptotagmin-1 to promote the formation of large, stable fusion pores via robust membrane penetration Article Open access 27 November 2023

Synaptotagmin-7 (Syt-7) is among the most Ca 2+ - sensitive synaptotagmins . It is one of two Ca 2+ -dependent synaptotagmins (along with Syt-9) that are abundant in pancreatic β-cells. Ca 2+ -dependent synaptotagmins bind Ca 2+ and membranes through their C2A and C2B domains, located at their C-terminus. In 2018, our lab worked with collaborators to write a comprehensive review article about ...

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MacDougall et al. review the structure and function of the calcium sensor synaptotagmin-7 in exocytosis.

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Synaptotagmin (Syt) proteins comprise a 17-member family, many of which trigger exocytosis in response to calcium. Historically, most studies have focused on the isoform Syt-1, which serves as the ...

Synaptotagmin 7 (SYT7) partly mediates AR, but substantial AR persists in the absence of SYT7. The closely related SYT3 binds Ca2+ and Sr 2+ with high affinity, making it a promising candidate to mediate AR. Here, we use knockout mice to study the contribution of SYT3 and SYT7 to AR at cerebellar and hippocampal synapses.