Bad And Bax

Overview of Bad And Bax

These findings reveal unexpectedly that despite the fact that activation of the BAD - BAX -caspase-3 pathway usually leads to cell death, neurons adopt this entire pathway for induction of LTD, and underscore the importance of quantitative differences in caspase-3 activation for determining the cellular function of this pathway.

As we can see from the illustration, Bad And Bax has many fascinating aspects to explore.

Mitochondrial Control of Apoptosis

Seizures may also induce dissociation of Bad from chaperone protein 14-3-3. Released Bad binds to Bcl-xl, provoking dissociation of Bax -Bcl-xl and Bax release. Bax penetrates the mitochondrial outer membrane and triggers cytochrome c release from the intermembrane space to the cytosol, where it activates caspase-9, which then activates caspase-3.